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We have shown, in collaboration with researchers at Humboldt University in Berlin, that three
Arabidopsis thaliana demethylase enzymes regulate the dynamics of repressive epigenetic marks and prevent their propagation outside their target sites in the genome, thus contributing to the robustness of the development of the plant.
Inside of eukaryotic cell nuclei, chromosomes are more or less compacted, along so-called "chromatin states" that condition the expression of genes they embed. Modifications of these chromatin states, targeted on thousands of genes, are a draining force for development in eukaryotes. Indeed, the differentiation of cells in various types is finely controlled by chemical modifications or "epigenetic marks", brought to the chromatin in a precise and very dynamic manner. These marks regulate access to genes for the transcription machinery, with permissive marks giving access and repressive marks preventing access. The mechanisms that regulate the dynamics of these marks and thereby build the individual body pattern remain poorly understood..
Collaboration: Department for Plant Cell and Molecular Biology, Institute for Biology (Humboldt-Universität Berlin, Germany); Cell & Plant Physiology Laboratory (Université Grenoble Alpes, France); National Key Laboratory of Crop Genetic Improvement (Huazhong Agricultural University, China); Max Planck Institute of Molecular Plant Physiology (Potsdam, Germany); Institute Plant Science Paris-Saclay (Université Paris-sud and Université Paris-Saclay, Orsay, France).
repressive marks correspond to posttranslational modifications of trimethyl type, carried by Lysine 27 of Histone 3 (H3K27me3)
2 Pleiotropic: which affects several functions.
Yan W, Chen D, Smaczniak C, Engelhorn J, Liu H, Yang W, Graf A, Carles CC, Zhou DX and Kaufmann K
Dynamic and spatial restriction of Polycomb activity by plant histone demethylases.
Nature Plants, 2018
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