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Chromatin Dynamics and Developmental Transitions

Published on 10 May 2019
We aim at deciphering how the information contained in genomes is differentially used for developmental outputs. Plants, which perform flexible, life-long organogenesis, provide powerful genetic tools to understand how cell fates are acquired during morphogenetic programs. They thus bring unequaled opportunities to focus on fundamental questions on mechanisms controlling gene expression switches, such as chromatin dynamics (for stem cell maintenance vs differentiation) or nucleus-chloroplast communications (for launching and maintenance of photosynthetic cell fate).
We use an integrative approach connecting developmental processes, transcriptomes/epigenomes and molecular/atomic properties of individual regulators and protein complexes. For this, we combine our expertise in plant genetics and chromatin biology with local skills and infrastructures for structural biochemistry.


Team leader

Cristel Carles
Assistant Professor, Chair UGA/CNRS
Laboratoire de Physiologie Cellulaire & Végétale
CEA-Grenoble
17 avenue des Martyrs
38 054 Grenoble cedex 09
France
Phone: 33 (0)4 38 78 41 95
Fax: 33 (0)4 38 78 50 91

Biography (French)


Members of the team
Robert Blanvillain - Univ. Grenoble Alpes Assistant Professor - 04 38 78 34 84
Louise Chambon - PhD student - 04 38 78 34 84
Maha Chieb - PhD student - 04 38 78 37 53
François-Xavier Gillet - Univ. Grenoble Alpes Research engineer
Muriel Kabus, L3 Erasmus student,
Marie Le Masson, CNRS assistant engineer - 04 38 78 68 29
Thomas Pfannschmidt - Univ. Grenoble Alpes Professor - 04 38 78 05 69
Caroline Thouly, PhD student, ENS fellowship
Gilles Vachon, PhD, CNRS researcher, 04 38 78 41 95


Collaborators
Kerstin Kaufmann, Laboratory of Molecular Biology, Wageningen University, The Netherlands
Markus Schmid, Molecular Biology of Plants & Animals, Max Planck Institute for Developmental Biology, Tübingen, Germany
Frank Wellmer, Smurfit Institute of Genetics, Trinity College Dublin, Ireland
Leor Eshed Williams, The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Israël



Contracts and grants
CNRS Excellence Chair, University of Grenoble-Alpes (2009-2014)
ANR JCJC (2011-2014)
ADR (2011-2014), Rhône-Alpes region
French Ambassy Stipend to Julia Engelhorn<


Job opportuniities
We welcome enquiries from highly-motivated postdocs, graduate and master students wanting to contribute to the research topics developed in our team.



Keywords
Chromatin, transcriptional activation, plant development, stem cells, differentiation, flower morphogenesis, Arabidopsis thaliana